How does a potential drug discovered in the lab ultimately end up in people? We tackle this question in the context of exciting gene-modifying therapies called antisense oligonucleotides (ASOs). In this episode, we speak with Dr. Tim Miller to break down the science behind ASOs and learn more about his work in finding a cure for a genetic form of amyotrophic lateral sclerosis (ALS).
This episode was written and produced by Nancy Cai, Devika Nair, and Arja Ray.
Music used in this episode: “Thannoid”, “Bundt”, “Lupi”, “Partly Sage”, “Beignet”, “Trailrunner”, “Game Hens”, “Lord Weasel”, “The Zeppelin”, “Dorica”, “Our Fingers Cold”, “Gaena” by Blue Dot Sessions
For more information about spinal muscular atrophy (SMA), check out the spinal muscular dystrophy association website: https://www.mda.org/disease/spinal-muscular-atrophy.
There is also this great animation that shows how the Spinraza (nusinersen) ASO works in the body: https://www.spinraza.com/en_us/home/taking/how-spinraza-works.html.
To read the results from the first ASO for Huntington’s disease, check out the New England Journal of Medicine article here: https://www.nejm.org/doi/full/10.1056/NEJMoa1900907?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed.
Did you know that mosquitoes kill over 700,000 people a year? They are the most dangerous animal in the world. How can they be stopped?!
In this episode, we spoke with a variety of experts that are working on mosquito vector control in the Caribbean and Latin America. The common theme is that it is essential to educate community members about the risks of mosquitoes and actions that they can take to reduce mosquito breeding. An educated community is much more engaged to take actions to prevent mosquito borne diseases like Zika and dengue. We also spoke to the World Mosquito Program about their research on infecting mosquitoes with a harmless bacteria called Wolbachia that prevents the mosquitoes from being able to spread disease. Although progress is being made, it will take a lot of money, resources, and new technology to eliminate the spread of mosquito-borne diseases.
You can check out the USAID Zika photo exhibit, which featured clips from some of the interviews in this episode, at https://spark.adobe.com/page/PdfTwBPiuCH3F/
You probably haven’t heard much about the Zika epidemic in the last few years – whatever happened with Zika? In this episode, we follow the history of Zika – from its origins, to the widespread epidemic of 2015-2016, to the personal impact it had on those who were affected, to its disappearance, and to the possibility of preventing a future Zika epidemic through a vaccine. We spoke with Dalma Contina Soto, a mother of a child born with congenital Zika syndrome; Dr. Josefina Coloma, an epidemiologist who studies the Zika virus and works to prevent mosquito-borne diseases in Nicaragua; and Dr. Anna Durbin, an infectious disease specialist who tests potential vaccines for Zika and Dengue.
To listen to the original Spanish audio of Dalma’s interview, head to soundcloud.com/carrytheoneradio and look for the playlist “Zika miniseries – Spanish audio”.
Some of this content was originally featured as an audio companion to a USAID photo exhibit detailing efforts to combat Zika in Latin America and the Caribbean. To check out the photos, go to https://spark.adobe.com/page/PdfTwBPiuCH3F/.
This episode is part of a 2-part miniseries – the next episode, all about prevention of mosquito-borne diseases like Zika, releases on September 16th. Stay tuned!
The genome is like the encyclopedia to our body. With all that information, how does each cell know what part of the genome to read out at the right place and right time? That’s where transcription factors come to play. In this episode, we’ll learn how transcription factors prevent eyeballs from growing in our bellies! We will also hear from Dr. Aseem Ansari as he speaks about his work on creating synthetic transcription factors, SynGRs, and how these molecules could be used in future therapies.
This episode was written and produced by Devika Nair, Nancy Cai, and Arja Ray. Music used in this episode: “Picnic March”, “Filing Away”, “Tiny Putty”, “Borough”, “Beignet”, “Trailrunner”, “Lovers Hollow”, “Highway 94”, “Dangerous Swing”, “Curio” by Blue Dot Sessions.
Hey! Sorry we didn't have an episode out in July, but we have been hard at work creating our next season of episodes. We'll be talking about the Zika virus, how to stop mosquitoes from spreading disease, how to use molecules to turn genes on and off, black holes, brain development, and more! Plus, we'll be starting our Young Scientists Spotlight series to highlight the work done by graduate students and postdocs towards scientific advancement. Episodes will be dropping on the first Monday of each month, plus occasional bonus episodes mid-month. See you soon, and stay curious!
This month, we discuss one of the biggest buzzwords in science today: CRISPR. This gene-editing tool has gotten a lot of attention for some ...ethically dubious uses, but before we humans got our hands on it, CRISPR was actually one of nature’s inventions. Since its discovery, CRISPR has been widely adapted as an incredibly effective research tool, but we’re still working to understand its biology -- and its limitations. In this episode, you’ll hear from Dr. Joseph Bondy-Denomy, who researches the evolutionary arms race that led to CRISPR, and Dr. Martin Kampmann, who uses CRISPR as a tool to study disease.
In the early 80s, a new disease appeared in San Francisco, baffling scientists and alarming the public. Since then, our understanding of HIV/AIDS has made enormous strides, with treatments and prevention making leaps and bounds too. However, these advances haven't reached everyone quite yet. In a live recording, we speak to five people who have been instrumental in shaping HIV/AIDS treatment, policy, and care in San Francisco and abroad, and ask them about the barriers that still remain today.
Recorded during a live event at UCSF Alumni Weekend.
Hosted by Ben Mansky and Anna Lipkin
Written and produced by Ben Mansky, Anna Lipkin, Katie Cabral, Stephanie Wankowicz, Liron Noiman, and Yiqi Cao
Music in this episode:
Thought Bubbles by Lee Rosevere
String in a Box
Hundred Mile by Blue Dot Sessions
Episode Art courtesy of UCSF Archives AIDS History Project
Pseudoscience: we know it when we see it, right? Or do we? On this episode of Carry the One Radio, we tackle the dirtiest word in science with the help of science historian Dr. Michael Gordin. Hear a few of our favorite pseudoscience stories, and see how pseudoscience can help us define the sometimes fuzzy borders of science. Plus, we discuss what to do about all that pesky pseudoscience floating around. Buckle up, it’s the Pseudoscience Episode.
Hosted and Produced by Anna Lipkin, Devika Nair, and Liron Noiman
Music used in this episode:
"Filaments", "Curious Process" and "The Ascent" by Podington Bear
"Transitioning" by Lee Rosevere
"Bastien und Bastienne", "Adagio for Glass Armonica in C Major" and "Laudate Dominum" by Wolfgang Amadeus Mozart
"Lupi" and "Chicken Steak" by Blue Dot Sessions
From Google Maps to John Snow’s map of cholera cases in the 1800s, maps have the power to change the way we understand information. What if we could use maps of cellular function to discover the mechanisms of psychiatric disorders? We sit down with Dr. Jeremy Willsey, a researcher in the Psychiatric Cell Map Initiative, who’s trying to do just that—understand the neural basis of Tourette Disorder by placing disorder-related mutations on a map of the cell.
Hosted by Carlos Johnson-Cruz and Li Wang
Produced by Anna Lipkin, Stephanie Wankowicz, Li Wang, and Carlos Johnson-Cruz
Editing Help from the CTOR team
Music used in this episode:
“Scenery” and “Ode to the World” by Kai Engel
“Bathed in Light” and “Unanswered Questions” by Kevin MacLeod
“Frogs in Tuxes” and “Sweet and Clean” by Podington Bear
“Ragtime Dance” by Scott Joplin
If you stop to think about it, the amount of data we generate every day is truly mind-blowing - so much so that it's changing the way we live. In fact, our ability to quantify and measure large biological datasets has revolutionized the way we study and treat human diseases. In this episode, we speak to Dr. Atul Butte, who exploits these massive, publicly-available datasets to create novel and effective therapies for those in need.
Music in this episode includes:
Blue Dot Sessions: Borough, Beignet, Game Hens, The Zeppelin, Hundred Mile, Lord Weasel, Dorica
Podington Bear: Cascades, Window Shopping, Daydreamer
Musick's Recreation, Milena Cord-to-Krax: Gavotte (BWV 995)