This month, we discuss one of the biggest buzzwords in science today: CRISPR. This gene-editing tool has gotten a lot of attention for some ...ethically dubious uses, but before we humans got our hands on it, CRISPR was actually one of nature’s inventions. Since its discovery, CRISPR has been widely adapted as an incredibly effective research tool, but we’re still working to understand its biology -- and its limitations. In this episode, you’ll hear from Dr. Joseph Bondy-Denomy, who researches the evolutionary arms race that led to CRISPR, and Dr. Martin Kampmann, who uses CRISPR as a tool to study disease.
In the early 80s, a new disease appeared in San Francisco, baffling scientists and alarming the public. Since then, our understanding of HIV/AIDS has made enormous strides, with treatments and prevention making leaps and bounds too. However, these advances haven't reached everyone quite yet. In a live recording, we speak to five people who have been instrumental in shaping HIV/AIDS treatment, policy, and care in San Francisco and abroad, and ask them about the barriers that still remain today.
Recorded during a live event at UCSF Alumni Weekend.
Hosted by Ben Mansky and Anna Lipkin
Written and produced by Ben Mansky, Anna Lipkin, Katie Cabral, Stephanie Wankowicz, Liron Noiman, and Yiqi Cao
Music in this episode:
Thought Bubbles by Lee Rosevere
String in a Box
Hundred Mile by Blue Dot Sessions
Episode Art courtesy of UCSF Archives AIDS History Project
Pseudoscience: we know it when we see it, right? Or do we? On this episode of Carry the One Radio, we tackle the dirtiest word in science with the help of science historian Dr. Michael Gordin. Hear a few of our favorite pseudoscience stories, and see how pseudoscience can help us define the sometimes fuzzy borders of science. Plus, we discuss what to do about all that pesky pseudoscience floating around. Buckle up, it’s the Pseudoscience Episode.
Hosted and Produced by Anna Lipkin, Devika Nair, and Liron Noiman
Music used in this episode:
"Filaments", "Curious Process" and "The Ascent" by Podington Bear
"Transitioning" by Lee Rosevere
"Bastien und Bastienne", "Adagio for Glass Armonica in C Major" and "Laudate Dominum" by Wolfgang Amadeus Mozart
"Lupi" and "Chicken Steak" by Blue Dot Sessions
From Google Maps to John Snow’s map of cholera cases in the 1800s, maps have the power to change the way we understand information. What if we could use maps of cellular function to discover the mechanisms of psychiatric disorders? We sit down with Dr. Jeremy Willsey, a researcher in the Psychiatric Cell Map Initiative, who’s trying to do just that—understand the neural basis of Tourette Disorder by placing disorder-related mutations on a map of the cell.
Hosted by Carlos Johnson-Cruz and Li Wang
Produced by Anna Lipkin, Stephanie Wankowicz, Li Wang, and Carlos Johnson-Cruz
Editing Help from the CTOR team
Music used in this episode:
“Scenery” and “Ode to the World” by Kai Engel
“Bathed in Light” and “Unanswered Questions” by Kevin MacLeod
“Frogs in Tuxes” and “Sweet and Clean” by Podington Bear
“Ragtime Dance” by Scott Joplin
If you stop to think about it, the amount of data we generate every day is truly mind-blowing - so much so that it's changing the way we live. In fact, our ability to quantify and measure large biological datasets has revolutionized the way we study and treat human diseases. In this episode, we speak to Dr. Atul Butte, who exploits these massive, publicly-available datasets to create novel and effective therapies for those in need.
Music in this episode includes:
Blue Dot Sessions: Borough, Beignet, Game Hens, The Zeppelin, Hundred Mile, Lord Weasel, Dorica
Podington Bear: Cascades, Window Shopping, Daydreamer
Musick's Recreation, Milena Cord-to-Krax: Gavotte (BWV 995)
The heart is an extremely complicated organ, and believe it or not, everyone has one! But how does this vital organ come to be? By studying how a stem cell makes the decision to become a heart cell, Dr. Daniel Hart is trying to figure that out, and he’s using fish to do it. Check out this episode for some pretty terrible puns, fascinating facts about zebrafish, and an extended metaphor about gene regulation that will make you want to reach for the liquor cabinet.
Music from Podington Bear on the Free Music Archive, and sound effects from users agonda and philberts on Freesound.com.
Dr. Liz Wayne got her start as a cancer hunter, searching for rogue cells running loose through the bloodstream. But she started to notice something strange – everywhere she found cancer cells, she found immune cells, too. Today, a big issue with cancer therapy is that some cancer sites are really hard to reach, but immune cells have no problem getting there. Dr. Wayne thought, why not hitchhike cancer-fighting drugs onto immune cells to get them straight to the places they’re needed most? Listen to this month’s episode to find out how her research may pave the way for a cheaper, more accessible kind of cancer immunotherapy. Plus, stick around after the credits to hear the origin story of Dr. Wayne’s podcast, PhDivas.
Sharing is caring - so what if you could transmit your HIV therapy to someone else? In this episode, we talked to Dr. Leor Weinberger, whose team has invented TIPs, or Therapeutic Interfering Particles, that are mutant, shortened forms of HIV that cannot replicate on their own and cannot cause disease. In cells that contain HIV, these TIPs outcompete HIV, preventing it from replicating. These TIPs could then be spread from person to person through the same ways that HIV is transmitted. This therapy could go a long way towards fighting the barriers against disease control - adherence, access, and resistance.
We thought this was a really unique idea that has the potential of reducing the population level of HIV, and we wanted to share this early-stage research with you.
To date, cochlear implants are the most successful electronic device for restoring sensation in individuals with sensorineural hearing loss. Yet these devices are not without flaws. For instance, pitch perception is extremely poor in these devices, and that can affect an implant user's ability to distinguish sounds in a noisy room. In this episode, we speak to Dr. Charles Limb, a UCSF ear surgeon who specializes in hearing loss and performs these cochlear implant surgeries. By incorporating complex elements of music, Dr. Limb and his team hope to improve the current cochlear implant model so those with hearing loss have a wider range and more sensitive ability to hear.
Dr. David Gordon studies HIV. In Life/Science, a new mini-series produced in collaboration with the UCSF Quantitative Biosciences Institute, we're giving you a peek behind the curtain. This isn't just a series about science, it's also about the process, about what it actually means to do this kind of research - including the confusion, failures, and triumphs David has faced along the way.
Life/Science will be updated monthly, so make sure to tune in next month for Episode 2: Methods! We'll take a deep dive into the experiments David used to figure out how HIV hijacks human cells for its own nefarious purposes.
If you like what you hear, leave us a comment or review! We'd love to hear from you. Music featured in this episode comes from Podington Bear.