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Carry the One Radio: The Science Podcast
Igniting Scientific Curiosity
Category: Life Sciences
Location: San Francisco
Carry the One is a small team of young scientists at UCSF who are passionate about bringing science stories straight to the public's ear in an entertaining, digestible way. Tune in for stories ranging from current research to science history, from med ...more
Carry the One is a small team of young scientists at UCSF who are passionate about bringing science stories straight to the public's ear in an entertaining, digestible way. Tune in for stories ranging from current research to science history, from medical science to the natural and social sciences. -- Visit us at carrytheoneradio.com Twitter: @CTORadio Instagram: @carrytheoneradio To support the show: www.patreon.com/carrytheone
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Science is one of the most powerful influences in our lives. The medicines we use, the foods we eat, the technologies we have –...


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February 17, 2020 08:57 AM PST

Welcome to our third installment of “The Spotlight”! In this episode, we interviewed Dr. Armen Moughamiam, who is a neurology fellow at UCSF and an ambassador to both science and medicine. We discuss the educational journey of an MD/PhD, experiencing “unknown unknowns”, and staying motivated in this long (but rewarding!) path.

Music in this episode:
Borough by Blue Dot Sessions

Special thanks to Veronica Oberholzer and Kanchi Mehta for your first listens.

Music: Borough by Blue Dot Sessions

February 03, 2020 10:04 AM PST

A cell constantly interacts and adapts to its environment, making seemingly smart choices. But how can a single cell, without a centralized control center, solve such complex problems? Is there simple physics behind the complex measurement and feedback that goes on inside cells? In this episode, we speak to Dr. Wallace Marshall, Professor of Biochemistry and Biophysics at UCSF, about his work to determine how cells measure and regulate optimal size. In the process, we discuss diffusion, molecular motors, the cell’s ever-changing skeletons, and the idea of a software to engineer cells in the future.

This episode was written and produced by Arja Ray, Devika Nair, and Katie Cabral with editing help from the rest of the Carry the One Radio team. Music used in this episode includes Partly Sage, Denzel Sprak, Hundred Mile, Tiny Putty, Highway 94, Guild Rat, Game Hens, The Zeppelin, Beignet, Balti, Loopy, Dorica, and Dance of Felt by Blue Dot Sessions.

Cover Image by Yuri Korchmar.

Check out this animation of a molecular motor carrying cargo on a microtubule: https://www.youtube.com/watch?v=xlPDEpimzB8

For more information on Dr. Marshall’s work: https://cellgeometry.ucsf.edu/

January 21, 2020 10:00 AM PST

In this episode, we’re turning back the clock to our earliest days - just after birth. What happens to our brains in this sensitive time of life? More than we ever thought, it turns out. We spoke with Dr. Mercedes Paredes, assistant professor of neurology at UCSF, to learn more about how humans’ brain cells are still moving and changing even after we’re born. As we learn more about the brain’s initial stages, we can better understand its vulnerabilities. Not only that, but we can also figure out how to intervene early on to stave off neurological problems like psychiatric illness or epilepsy.

This episode was written and produced by Stella Belonwu, Rebecca Fang, Deanna Necula, and Ben Mansky. Music in this episode includes “A Day at the Park,” “Fomalhaut,” and “Convergence” by Pictures of the Floating World and “Autowaschanlage Instrumental” by Lobo Loco.

For more on recent developments with the HHS Fetal Tissue Ethics Review Board, see www.washingtonpost.com/health/trump-…aa_story.html.

January 06, 2020 08:30 AM PST

For this second installment of “The Spotlight” we spoke to Dr. Rachel Care, a newly minted PhD who studies how the retina adapts to losing vision. We talked about her path to research, the changing landscape of graduate education, and night vision goggles.

Music in this episode:
Thought Bubbles, Thinking It Over, Bigger Questions, Decompress, and Where Was I by Lee Rosevere

December 03, 2019 11:04 AM PST

Dr. David Gordon studies HIV. In Life/Science, a mini-series produced in collaboration with the UCSF Quantitative Biosciences Institute, we're giving you a peek behind the curtain. This isn't just a series about science, it's also about the process, about what it actually means to do this kind of research - including the confusion, failures, and triumphs David has faced along the way.

In the final episode of Life/Science, we reveal what David found in his gigantic experiment, and how his findings might lead to new avenues for HIV treatment. We also break down the process of how a scientific finding makes it from the lab to the world at large.

If you like what you hear, give us a like or leave a comment! We'd love to hear from you. Music featured in this episode comes from Podington Bear and Blue Dot Sessions. Other contributors to David's research include Ariane Watson, Assen Roguev, and Nevan Krogan. This episode was written and produced by Ben Mansky and Elina Kostyanovskaya, with help from Katie Cabral. Support for Life/Science comes from the Quantitative Biosciences Institute at UCSF.

November 18, 2019 10:00 AM PST

Dr. David Gordon studies HIV. In Life/Science, a mini-series produced in collaboration with the UCSF Quantitative Biosciences Institute, we're giving you a peek behind the curtain. This isn't just a series about science, it's also about the process, about what it actually means to do this kind of research - including the confusion, failures, and triumphs David has faced along the way.

Life/Science will be updated bi-weekly, so make sure to tune in on December 2nd for Episode 3: Results! Next time, we’ll hear what David’s experiment revealed, and its implications for the world at large.

If you like what you hear, give us a like or leave a comment! We'd love to hear from you. Music featured in this episode comes from Podington Bear and Blue Dot Sessions. Other contributors to David's research include Ariane Watson, Stefanie Jager, and Assen Roguev. This episode was written and produced by Katie Cabral, Ben Mansky, and Elina Kostyanovskaya. Support for Life/Science comes from the Quantitative Biosciences Institute at UCSF.

November 12, 2019 08:13 AM PST

When you close your eyes and imagine the universe, what do you see? Maybe you picture billions of swirling galaxies made of dust, gas, stars, and planets. But, what if we told you that the major source of mass in the universe is made out of something we cannot see? Not only can we not see it, we aren’t even entirely sure what it is. This mysterious cosmic substance is called dark matter, and it is the subject of this episode.

To learn about dark matter, we spoke to Dr. Neta Bahcall, the Eugene Higgins Professor of Astrophysics at Princeton University. We discuss how it was discovered, as well as how astrophysicists are certain it exists, but are still frustrated by the elusive nature of the particles that make up dark matter. We also discuss some of the work currently being done to better understand what dark matter is, how it’s distributed in the universe, and what effect it has on the structure and evolution of the universe.

This episode was written & produced by Stella Belonwu, Anna Lipkin, Cindy Liu and Liron Noiman.

For more information on dark matter, check out Modelling the Invisible (https://www.modellinginvisible.org/dark-matter/) and The Illustris Simulation (https://www.illustris-project.org/about/). Additionally, to understand some of the concepts that we touched on, check out The Physics Hypertextbook (https://physics.info/standard/).

The cover art for this episode is an image of the Abell 2218 galaxy cluster and beautifully demonstrates the effect of gravitational lensing, which we discuss in the episode [30:46]. The image was pulled from https://www.spacetelescope.org/images/heic0814a/, with credits to NASA, ESA, and Johan Richard from Caltech, with acknowledgements to Davide de Martin & James Long (ESA/Hubble).

Music and sound effects were acquired from the YouTube Audio Library, www.freesound.org, and Free Music Archive.

Music included in this episode:
Algorithms and Moonrise by Chad Crouch
Saturn V by Lee Rosevere
Cute Avalanche by RKVC
English Country Garden by Aaron Kenny
Orbital Romance by Sir Cubworth
Alive Evil by Hainbach
Ether Oar by The Whole Other
Da Jazz Blues by Doug Maxwell

November 04, 2019 09:38 AM PST

Dr. David Gordon studies HIV. In Life/Science, a new mini-series produced in collaboration with the UCSF Quantitative Biosciences Institute, we're giving you a peek behind the curtain. This isn't just a series about science, it's also about the process, about what it actually means to do this kind of research - including the confusion, failures, and triumphs David has faced along the way.

Life/Science will be updated bi-weekly, so make sure to tune in on the 18th for Episode 2: Methods! We'll take a deep dive into the experiments David used to figure out how HIV hijacks human cells for its own nefarious purposes.

If you like what you hear, give us a like or leave a comment! We'd love to hear from you. Music featured in this episode comes from Podington Bear. Other contributors to David's research include Ariane Watson, Stefanie Jager, and Assen Roguev.

October 22, 2019 09:38 AM PDT

We’re proud to present the first episode in our brand new Young Scientist Spotlight Series, or “The Spotlight” for short. Each month, we’ll feature an informal, lightly-edited interview with a graduate student, postdoc, staff researcher, or other early-career scientist. Through these conversations, we’ll be bringing you a fun, down-to-earth look at not only even more of the awesome science content you love, but also the people behind the science. In our first Spotlight, we spoke with Witney Chen, a graduate student studying Parkinson’s Disease at the University of California, San Francisco. We chatted about her research on brain stimulation in human patients, life in graduate school, how she became a scientist, and… dog poop.

This episode was produced by Ben Mansky. Music is “Borough,” from Blue Dot Sessions.

October 14, 2019 10:02 AM PDT

How does a potential drug discovered in the lab ultimately end up in people? We tackle this question in the context of exciting gene-modifying therapies called antisense oligonucleotides (ASOs). In this episode, we speak with Dr. Tim Miller to break down the science behind ASOs and learn more about his work in finding a cure for a genetic form of amyotrophic lateral sclerosis (ALS).

This episode was written and produced by Nancy Cai, Devika Nair, and Arja Ray.

Music used in this episode: “Thannoid”, “Bundt”, “Lupi”, “Partly Sage”, “Beignet”, “Trailrunner”, “Game Hens”, “Lord Weasel”, “The Zeppelin”, “Dorica”, “Our Fingers Cold”, “Gaena” by Blue Dot Sessions

For more information about spinal muscular atrophy (SMA), check out the spinal muscular dystrophy association website: https://www.mda.org/disease/spinal-muscular-atrophy.

There is also this great animation that shows how the Spinraza (nusinersen) ASO works in the body: https://www.spinraza.com/en_us/home/taking/how-spinraza-works.html.

To read the results from the first ASO for Huntington’s disease, check out the New England Journal of Medicine article here: https://www.nejm.org/doi/full/10.1056/NEJMoa1900907?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed.

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